Taxim-O/Taxim-O 400/Taxim-O Kids Contraindications

Taxim-O/Taxim-O 400: Cefixime film-coated tablets/dispersible tablets are contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Anaphylactic/anaphylactoid reactions have been reported with the use of cefixime. Antibiotics, including cefixime, should be administered cautiously to any patient who has demonstrated some form of allergy, particularly to treatment with broad spectrum antibiotics, including cefixime tablets, alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is a primary cause of severe antibiotic-associated diarrhea including pseudomembranous colitis. Pseudomembranous colitis has been reported with the use of cefixime chewable tablets and other broad spectrum antibiotics; therefore, it is important to consider this diagnosis in patients who develop diarrhea in association with the use of antibiotics. Symptoms of pseudomembranous colitis may occur during or after antibiotic treatment and may range in severity from mild to life-threatening. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, management should include fluids, electrolytes, and protein supplementation. If the colitis does not improve after the drug has been discontinued, or if the symptoms are severe, oral vancomycin is the drug of choice for antibiotic-associated pseudomembranous colitis produced by C. difficile. Other causes of colitis should be excluded.
Taxim-O Kids: History of allergy to any ingredient of this product or other cephalosporins.
History of hypersensitivity to penicillins.